The Quacks of Quedlinburg: The Herb Witches expands the town of Quedlinburg with four new sets of items:

• The Witches – new characters with special abilities that players may use once per game
• Locoweed – a new ingredient whose value is determined by its ability rather than being fixed
• New ingredient books for each existing ingredient type, increasing variety even further
• Player components in black color – increasing the number of players to 5